For the home console Nintendo Switch, Wonder Boy: The Dragon’s Trap has a half-lizard, half-human protagonist who must adventure through the game looking for a cure. However, each dragon you slay transforms you again. Besides the lizard, you will become a hybrid of a mouse, a piranha, a lion, and a hawk.
From the fourth season of the animated TV show Ultimate Spider-Man, episode five, entitled “Lizards,” comes multiple Lizard transformations, mostly male, with a single female transformation. Video embedded in the main story.